Geez ! Nice card you have there ! I'm kinda jealous...

Try to replace Steamplay Dxvk version with the latest 1.0.1, apparently there's improvement for DMC 5. Didn't try it myself though...

Haha it is great, plays 4k games really smoothly!
Thanks for the tip. I'll give it a go over the weekend.

Read this: https://github.com/doitsujin/dxvk

State cache
DXVK caches pipeline state by default, so that shaders can be recompiled ahead of time on subsequent runs of an application, even if the driver's own shader cache got invalidated in the meantime. This cache is enabled by default, and generally reduces stuttering.

The following environment variables can be used to control the cache:

DXVK_STATE_CACHE=0 Disables the state cache.
DXVK_STATE_CACHE_PATH=/some/directory Specifies a directory where to put the cache files. Defaults to the current working directory of the application.

I just posted about this myself ( https://www.gamingonlinux.com/forum/topic/3839/page=1 ) . Did you ever manage to fix it or find out what the problem is? Both Proton and Wine+DXVK have this issue and to rule out DXVK I have the same issue with old DX9/DX8 games which should run flawlessly.

It seems to be to do with loading modules/textures into the scene that causes the problem.

Probably just compiling shaders. That said, Resident Evil 2 should have very few stutters once you reach the police station.

Thanks for the advice everyone. To be honest I have been busy on other games but I will get back to this one. On RE2 there is an annoying bug that you can't get past a loading screen for which you need a specific windows library...

I went back to devil may cry 5 and it runs really smoothly now.
Wow I'm impressed how much progress has been made to play windows games smoothly on linux.